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Artificial Sweeteners: A Poisoned Chalice



Anuj Maheshwari

 J Medi Ntri Vol 1 Issue 1 Page 70-72

R7. Artificial Sweeteners: A Poisoned Chalice

Author : Anuj Maheshwari 1 , Nisha Maheshwari 2 , Shivangi Maheshwari 2

1.Department of Medicine, Hind Institute of Medical Sciences, Lucknow, INDIA

2. Sri Harikamal Diabetes & Heart Clinic, Vikas Nagar, Lucknow


The use of artificial sweeteners as sugar substitutes has become widespread, but concerns about their potential health risks have been underscored by the World Health Organization (WHO)1, particularly regarding their possible association with cancer. Additionally, the pathophysiology and specific pathways targeted by these sweeteners have been subjects of interest in numerous studies.

The pathophysiology of the potential adverse effects of artificial sweeteners has been explored through various mechanisms. One such pathway is the alteration of gut microbiota, which has been linked to several diseases, including metabolic syndrome, type 2 diabetes, hyperlipidemia, and cardiovascular disorders. Dysbiosis induced by artificial sweeteners may play a significant role in these adverse health outcomes.2

Furthermore, studies have suggested that artificial sweeteners might accelerate senescence and atherosclerosis, potentially contributing to an increased risk of atrial fibrillation and age-related atrial fibrillation. Additionally, the association between artificial sweeteners and insulin resistance has been demonstrated in both animal models and human studies. Insulin resistance is closely linked to cardiovascular disease and has implications for overall health.3

Keywords: Gut Microbiota , Artificial Sweeteners atherosclerosis

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